STABILTY INDICATING ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF TOLVAPTAN IN BULK AND TABLET DOSAGE FORM BY HPLC AND UV

MOMIN AFFAN ABDUL JABBAR; SYED WAJAHAT SHAFAAT; H. PARAMESHWAR; A.V.JITHAN; SHAIKH MARUF FAHEMODDIN; sohail saleem khan; abdullah danish

STABILTY INDICATING ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF TOLVAPTAN IN BULK AND TABLET DOSAGE FORM BY HPLC AND UV

August 2022

Vol-8, Issue-4

Paper ID: 17915

ISSN: 2395-4396

Downloads: 0

Abstract & Details

Research Area

pharmacy

Keywords

Tolvaptan HPLC UV Method Development Validation

Abstract

To develop and validate a new, simple, rapid, precise and accurate to quantify Tolvaptan in raw material and dosage forms using C18 analytical column. Mobile phase consisted acetonitrile: water (45: 55 v/v), pumped at flow rate of 1.0 ml/min at ambient temperature and the run time was about 10 min with symmetrical peak. Tolvaptan detected by ultraviolet absorbance at 266 nm with no interference of commonly used excipients. The method was linear over the concentration range 5- 25 mcg/ml. the LOD and LOQ of Tolvaptan were 1.2845mcg/ml and 3.893mcg/ml. the result obtained showed good agreement with the declared contents in case of dosage forms.

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Author Information

#	Name	Institute / Affiliation
1	MOMIN AFFAN ABDUL JABBAR	OMEGA COLLEGE OF PHARMACY HYDRABAD
2	SYED WAJAHAT SHAFAAT	ISMAIL MEHTA COLLEGE OF PHARMACY AMBAD
3	H. PARAMESHWAR	OMEGA COLLEGE OF PHARMACY HYDRABAD
4	A.V.JITHAN	OMEGA COLLEGE OF PHARMACY HYDRABAD
5	SHAIKH MARUF FAHEMODDIN	ISMAIL MEHTA COLLEGE OF PHARMACY AMBAD
6	sohail saleem khan	ismail mehta college of pharmacy, ambad
7	abdullah danish	OMEGA COLLEGE OF PHARMACY HYDRABAD

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APA Style

JABBAR, MOMIN AFFAN ABDUL, SHAFAAT, SYED WAJAHAT, PARAMESHWAR, H., A.V.JITHAN, FAHEMODDIN, SHAIKH MARUF, khan, sohail saleem, & danish, abdullah (2022). STABILTY INDICATING ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF TOLVAPTAN IN BULK AND TABLET DOSAGE FORM BY HPLC AND UV. International Journal of Advance Research and Innovative Ideas In Education, 8(4), 1424-1431.

MLA Style

JABBAR, MOMIN AFFAN ABDUL, et al. "STABILTY INDICATING ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF TOLVAPTAN IN BULK AND TABLET DOSAGE FORM BY HPLC AND UV." International Journal of Advance Research and Innovative Ideas In Education, vol. 8, no. 4, 2022, pp. 1424-1431.

IEEE Style

MOMIN AFFAN ABDUL JABBAR, SYED WAJAHAT SHAFAAT, H. PARAMESHWAR, A.V.JITHAN, SHAIKH MARUF FAHEMODDIN, sohail saleem khan, and abdullah danish, "STABILTY INDICATING ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF TOLVAPTAN IN BULK AND TABLET DOSAGE FORM BY HPLC AND UV," International Journal of Advance Research and Innovative Ideas In Education, vol. 8, no. 4, pp. 1424-1431, 2022.

Vancouver Style

JABBAR MOMIN AFFAN ABDUL, SHAFAAT SYED WAJAHAT, PARAMESHWAR H., A.V.JITHAN, FAHEMODDIN SHAIKH MARUF, khan sohail saleem, et al. STABILTY INDICATING ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF TOLVAPTAN IN BULK AND TABLET DOSAGE FORM BY HPLC AND UV. International Journal of Advance Research and Innovative Ideas In Education. 2022;8(4):1424-1431.

Harvard Style

JABBAR, MOMIN AFFAN ABDUL, SHAFAAT, SYED WAJAHAT, PARAMESHWAR, H., A.V.JITHAN, FAHEMODDIN, SHAIKH MARUF, khan, sohail saleem, & danish, abdullah (2022) 'STABILTY INDICATING ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF TOLVAPTAN IN BULK AND TABLET DOSAGE FORM BY HPLC AND UV', International Journal of Advance Research and Innovative Ideas In Education, 8(4), pp. 1424-1431.

Chicago Style

JABBAR, MOMIN AFFAN ABDUL, et al. "STABILTY INDICATING ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF TOLVAPTAN IN BULK AND TABLET DOSAGE FORM BY HPLC AND UV." International Journal of Advance Research and Innovative Ideas In Education 8, no. 4 (2022): 1424-1431.

Turabian Style

JABBAR, MOMIN AFFAN ABDUL, et al. "STABILTY INDICATING ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF TOLVAPTAN IN BULK AND TABLET DOSAGE FORM BY HPLC AND UV." International Journal of Advance Research and Innovative Ideas In Education 8, no. 4 (2022): 1424-1431.