Chemistry and applications of organotin (IV) complexes of Schiff bases emphasizing their structural and functional diversity

Chemistry

Organotin(IV) complexes of Schiff bases have emerged as a versatile class of compounds due to their structural diversity and broad functional applications, primarily facilitated by their ability to coordinate with metal centers in multiple oxidation states, which leads to distinctive geometric configurations, including tetrahedral, octahedral, and trigonal bipyramidal structures; these complexes demonstrate remarkable stability attributed to the electronic and steric factors of Schiff base ligands and exhibit significant biological activities such as antimicrobial, antitumor, and DNA-binding capabilities, with studies employing techniques like density functional theory (DFT) and molecular docking revealing detailed mechanistic insights into their electronic configuration, charge transfer properties, and interaction dynamics with biological macromolecules, while experimental evaluations underscore their reduced cytotoxicity compared to traditional chemotherapeutic agents like cisplatin and potential for enhanced therapeutic efficacy against drug-resistant strains, making them a promising frontier for innovative drug design and advanced material development

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.