ACTIVITY OF CATALASE ENZYME IN DIABETIC RAT (RATTUS NORVEGICUS) MODELS AFTER ADMINISTRATION OF ETHANOL EXTRACT OF JENGKOL (ARCHIDENDRON PAUCIFLORUM) FRUIT PEEL

Zoological sciences

Jengkol fruit peel (Archidendron pauciflorum) from the Fabaceae family is one of the herbal plants used by the community in Karangwangi Village, Cianjur, West Java, as a remedy for diabetes mellitus (DM). DM is known to increase oxidative stress and cause high production of free radicals, thus requiring enzymatic antioxidants, such as catalase, to counteract free radicals. The aim of this study was to evaluate the activity of the catalase enzyme in diabetic rat (Rattus norvegicus) models after the administration of ethanol extract from jengkol (Archidendron pauciflorum) fruit peel (EEOJFP). The method used was experimental with a Completely Randomized Design (CRD) involving six treatments: diabetic rats; diabetic rats treated with glibenclamide at a dose of 10 mg/kg BW as a comparison; diabetic rats treated with EEOJPF at doses of 385, 770, and 1540 mg/kg BW; and non-diabetic rats, each with four replicates. The results showed that all treatments did not significantly affect catalase enzyme activity in blood cells. The concentration of catalase enzyme activity in the liver did not differ significantly from the group given glibenclamide, although this enzyme activity was lower compared to both the positive and negative controls. The conclusion of this study is that EEOJFP is not yet effective in significantly increasing catalase enzyme activity in blood cells and the liver of diabetic rat models, but its effect is comparable to that of glibenclamide.

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