EFFECTIVENESS OF THE COMBINATION OF CURCUMA XANTHORRHIZA AND AVERRHOA BILIMBI JUICE ON SWIMMING ABILITY AND HISTOLOGICAL OF BRAIN RATS

Biological Sciences

The medicinal plants Curcuma xanthorrhiza and Averrhoa bilimbi are known to contain compounds that have antioxidant activity. Flavonoids are antioxidant compounds that can overcome fatigue. The objective of study was to investigate the effect of the combination of Curcuma xanthorrhiza and Averrhoa bilimbi on swimming ability and histological of brain Rats. The research method used a Completely Randomized Design using twenty-four male Wistar Rats (Rattus norvegicus) with the following treatment arrangements NC (aquabidest 3 mL), PC (herbadrink dosage 2.5 g/kgbw), P1 (plant juice dosage 20 g/kgbw), P2 (plant juice dosage 15 g/kgbw), P3 (plant juice dosage 10 g/kgbw), P4 (plant juice dosage 5 g/kgbw) given orally for 28 days. The parameters observed were swimming ability and histological of brain rats. The results showed that the administrastion combination of C. xanthorrhiza and A. bilimbi can improve swimming ability in rats but based on histological observations there is necrosis in neuroglia cells. The conclusion of the study is that although there is neuroglial cell necrosis, the combination administration is not toxic to the brain because it can affect the increase in stamina and the recommended dose is P4 (5 g/kgbw) because it has the lowest percentage of necrosis but also increases the rat's swimming ability.

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