The influence of Cola Nitida on Testosterone and Progesterone Concentrations in the Underweight Humans Under Resting Condition in Ambrose Alli University.

Physiology

In quest of a stimulant to cope with rather challenging activities, some individuals take to the consumption of Cola nitida. The most active ingredient, caffeine, could be responsible for the physiological or clinical effects of Cola nitida in humans. From some published evidences of the high prevalence of infertility nowadays, the need for this study was thereby necessitated. Here we report the influence of Cola nitida on testosterone and progesterone concentrations in the underweight humans under resting condition in Ambrose Alli University. Twenty (20) underweight volunteers (10 males and 10 females) and non-habitual Cola nitida chewers, aged 18-28 years were used for the study. 0.5g/kg body weight of Cola nitida was administered to each subject to be chewed as a bolus. After ingestion, 50ml of water was given to each volunteer to flush the masticated Cola nitida down the gut. The subject was allowed to rest for 90 minutes. Blood sample was collected from the medial cubital vein using vacutainer syringe. The radio-immunoassay principle was used for the estimation of testosterone and progesterone levels. The results showed that Cola nitida consumption by the underweight female subjects reduced serum levels of Progesterone (from 2.960±0.9631 nmol/L to 2.530±0.912 nmol/L) but increased serum levels of Testosterone (from 2.640±0.3433 to 3.640±0.682 nmol/L). The change, however, was not significant (P>0.05). We show that Cola nitida, at the specific dosage, could reduce the chances of fertility in the female but increases that of the male underweight subjects.

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