In-silico studies on phytochemical, Carpaine in papaya leaves

Dr Heena V Sanghani; Dr Sunita D Shirke; Ms. Pratiksha U Kurne

In-silico studies on phytochemical, Carpaine in papaya leaves

August 2023

Vol-9, Issue-4

Paper ID: 21419

ISSN: 2395-4396

Downloads: 0

Abstract & Details

Research Area

Applied Chemistry

Keywords

Phytochemical Carica papaya leaves anti-cancer Ligand protein interactions Carpaine binding affinity structure-based drug design

Abstract

Cyclin dependent kinases are critical molecules that control cell cycle progression from one phase to the other. In humans, mutations in cyclin dependent kinase 2 (1GII) is responsible for nearly 50% of cancers. This study evaluates in-vitro and in-silico study of a phytochemical carpaine obtained from Carica papaya leaves.. Computational docking was used to predict conformations and free binding energy for ligand carpaine with CDK4 protein 1GII. In silico studies were done on different conformers of ligand carpaine and receptor 1GII, a CDK4 protein which gives binding free energy of -7.44 Kcal/ mole. This study reveals the pharmacokinetic properties and Lipinski’s rule of five. Two hydrogen bonds were also obtained between them. Docking results for carpaine may be promising towards it as anticancer drug candidate.

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Author Information

#	Name	Institute / Affiliation
1	Dr Heena V Sanghani	Vivekanand College Kolhapur, Maharashtra, India
2	Dr Sunita D Shirke	Vivekanand College Kolhapur, Maharashtra, India
3	Ms. Pratiksha U Kurne	Vivekanand College Kolhapur, Maharashtra, India

How to Cite

Use the following formats to cite this article in your research.

APA Style

Sanghani, Dr Heena V, Shirke, Dr Sunita D, & Kurne, Ms. Pratiksha U (2023). In-silico studies on phytochemical, Carpaine in papaya leaves. International Journal of Advance Research and Innovative Ideas In Education, 9(4), 2879-2885.

MLA Style

Sanghani, Dr Heena V, et al. "In-silico studies on phytochemical, Carpaine in papaya leaves." International Journal of Advance Research and Innovative Ideas In Education, vol. 9, no. 4, 2023, pp. 2879-2885.

IEEE Style

Dr Heena V Sanghani, Dr Sunita D Shirke, and Ms. Pratiksha U Kurne, "In-silico studies on phytochemical, Carpaine in papaya leaves," International Journal of Advance Research and Innovative Ideas In Education, vol. 9, no. 4, pp. 2879-2885, 2023.

Vancouver Style

Sanghani Dr Heena V, Shirke Dr Sunita D, Kurne Ms. Pratiksha U. In-silico studies on phytochemical, Carpaine in papaya leaves. International Journal of Advance Research and Innovative Ideas In Education. 2023;9(4):2879-2885.

Harvard Style

Sanghani, Dr Heena V, Shirke, Dr Sunita D, & Kurne, Ms. Pratiksha U (2023) 'In-silico studies on phytochemical, Carpaine in papaya leaves', International Journal of Advance Research and Innovative Ideas In Education, 9(4), pp. 2879-2885.

Chicago Style

Sanghani, Dr Heena V, Dr Sunita D Shirke, and Ms. Pratiksha U Kurne. "In-silico studies on phytochemical, Carpaine in papaya leaves." International Journal of Advance Research and Innovative Ideas In Education 9, no. 4 (2023): 2879-2885.

Turabian Style

Sanghani, Dr Heena V, Dr Sunita D Shirke, and Ms. Pratiksha U Kurne. "In-silico studies on phytochemical, Carpaine in papaya leaves." International Journal of Advance Research and Innovative Ideas In Education 9, no. 4 (2023): 2879-2885.