Formulation and Evaluation of Nanosuspension of Antiviral Ophthalmic Application

M. Pharmacy

Formulation and evaluation of Nanosuspension of Acyclovir for ophthalmic application.In this study, an attempt was made to improve the solubility and dissolution characteristics of a poorly soluble drug (Acyclovir) using nanosuspension technology.To improve the solubility. To formulate and evaluate acyclovir loaded nanosuspension Optimization of formulation and process parameters enhanced corneal residence time.To achieve sufficient drug concentration at absorption site, improve Therapeutic effect and lower dose with better patient compliance. Results conclusively prove that Acyclovir nanosuspension prepared by high speed homogenization method. Different excipients are used in formulation like Poloxamer-188, PVP K-90, different concentrations. F5 batch has shown the better results in high speed homogenization Different excipients were shown variation in particle size, DSC study, drug content, entrapment efficiency and in-vitro dissolution study. Optimized formulation was chosen on the basis of results obtained from particle size and entrapment efficiency. The combination of excipients yields nanosuspension with the smallest average particle size and by the transformation of the nanosuspension into the physical stability of this system could be further enhanced

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