Development, Optimization, and In-Vitro Evaluation of Mucoadhesive Famciclovir 500 mg Oral Mucosal Tablets for Enhanced Bioavailability and Improved Patient Compliance

Mr.Gaurav Shirsath; Prof. Ashwini Wakade; Dr.Megha Salve

Development, Optimization, and In-Vitro Evaluation of Mucoadhesive Famciclovir 500 mg Oral Mucosal Tablets for Enhanced Bioavailability and Improved Patient Compliance

May 2025

Vol-11, Issue-3

Paper ID: 26451

ISSN: 2395-4396

Downloads: 0

Abstract & Details

Research Area

Pharmacy

Keywords

Famciclovir Oral Mucosal Tablet Mucoadhesive Drug Delivery Fast Dissolving Tablets Antiviral Therapy Buccal Absorption In-vitro Evaluation Carbopol HPMC Bioavailability Enhancement

Abstract

Abstract - The present research focuses on the formulation and evaluation of Famciclovir 500 mg oral mucosal tablets intended for the effective and patient-friendly treatment of viral infections such as herpes zoster and herpes simplex. Famciclovir, a prodrug of penciclovir, suffers from limited oral bioavailability due to hepatic first-pass metabolism. To overcome this limitation and improve therapeutic efficacy, an oral mucosal tablet was designed to allow direct absorption through the oral mucosa, thereby bypassing hepatic metabolism.The formulation process employed a combination of mucoadhesive and disintegration-promoting excipients. Hydroxypropyl Methylcellulose (HPMC) and Carbopol 974P were selected for their excellent mucoadhesive properties, while Croscarmellose Sodium served as a superdisintegrant to ensure rapid tablet disintegration. Additional ingredients such as Polysorbate 80 and Sodium Lauryl Sulfate were incorporated to enhance solubility and drug dispersion. Polyvinylpyrrolidone (PVP) K30 was used as a binder, and patient acceptability was increased with the addition of aspartame and peppermint flavor. Microcrystalline Cellulose was employed as a diluent to achieve the desired tablet weight and compressibility.

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Author Information

#	Name	Institute / Affiliation
1	Mr.Gaurav Shirsath	Shivajirao Pawar College of Pharmacy
2	Prof. Ashwini Wakade	Shivajirao Pawar College of Pharmacy
3	Dr.Megha Salve	Shivajirao Pawar College of Pharmacy

How to Cite

Use the following formats to cite this article in your research.

APA Style

Shirsath, Mr.Gaurav, Wakade, Prof. Ashwini, & Salve, Dr.Megha (2025). Development, Optimization, and In-Vitro Evaluation of Mucoadhesive Famciclovir 500 mg Oral Mucosal Tablets for Enhanced Bioavailability and Improved Patient Compliance. International Journal of Advance Research and Innovative Ideas In Education, 11(3), 342-354.

MLA Style

Shirsath, Mr.Gaurav, et al. "Development, Optimization, and In-Vitro Evaluation of Mucoadhesive Famciclovir 500 mg Oral Mucosal Tablets for Enhanced Bioavailability and Improved Patient Compliance." International Journal of Advance Research and Innovative Ideas In Education, vol. 11, no. 3, 2025, pp. 342-354.

IEEE Style

Mr.Gaurav Shirsath, Prof. Ashwini Wakade, and Dr.Megha Salve, "Development, Optimization, and In-Vitro Evaluation of Mucoadhesive Famciclovir 500 mg Oral Mucosal Tablets for Enhanced Bioavailability and Improved Patient Compliance," International Journal of Advance Research and Innovative Ideas In Education, vol. 11, no. 3, pp. 342-354, 2025.

Vancouver Style

Shirsath Mr.Gaurav, Wakade Prof. Ashwini, Salve Dr.Megha. Development, Optimization, and In-Vitro Evaluation of Mucoadhesive Famciclovir 500 mg Oral Mucosal Tablets for Enhanced Bioavailability and Improved Patient Compliance. International Journal of Advance Research and Innovative Ideas In Education. 2025;11(3):342-354.

Harvard Style

Shirsath, Mr.Gaurav, Wakade, Prof. Ashwini, & Salve, Dr.Megha (2025) 'Development, Optimization, and In-Vitro Evaluation of Mucoadhesive Famciclovir 500 mg Oral Mucosal Tablets for Enhanced Bioavailability and Improved Patient Compliance', International Journal of Advance Research and Innovative Ideas In Education, 11(3), pp. 342-354.

Chicago Style

Shirsath, Mr.Gaurav, Prof. Ashwini Wakade, and Dr.Megha Salve. "Development, Optimization, and In-Vitro Evaluation of Mucoadhesive Famciclovir 500 mg Oral Mucosal Tablets for Enhanced Bioavailability and Improved Patient Compliance." International Journal of Advance Research and Innovative Ideas In Education 11, no. 3 (2025): 342-354.

Turabian Style

Shirsath, Mr.Gaurav, Prof. Ashwini Wakade, and Dr.Megha Salve. "Development, Optimization, and In-Vitro Evaluation of Mucoadhesive Famciclovir 500 mg Oral Mucosal Tablets for Enhanced Bioavailability and Improved Patient Compliance." International Journal of Advance Research and Innovative Ideas In Education 11, no. 3 (2025): 342-354.