Synthesis, Spectral Characterization, and In Vitro Antibacterial and Antifungal Activities of Some New Heterocycles Containing Nitrogen and Sulphur.

CHEMISTRY

The antimicrobial activity of newly synthesized linear monoazaphenothiazine derivatives; 3-benzamido-1-azaphenothiazine, 3-trifluoromethamido-1-azaphenothiazine, 3-trichloromethanamido-1-azaphenothiazine and 3-(4-nitrobenzamido)-1- azaphenothiazine have been evaluated against bacteria and fungal strains. Results demonstrated that majority of the linear monoazaphenothiazine derivatives were very active against the tested bacteria. The association between antibacterial action and the chemical structure of phenothiazines was explored. Thiazine moieties contained in compounds show variety of therapeutic properties such as antihypertensive, antitumor, antibiotic, antibacterial, anticoagulant, antifungal, anticancer, and antiviral. This review is largely centered on thiazines and their derivatives with potential antibacterial activity that are at this moment in progress.

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