FORCE DEGRADATION STABILITY INDICATING STUDIES AND ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF FAVIPIRAVIR BY HPLC- UV IN BULK AND PHARMACEUTICAL DOSAGE FORMS

Pharmacy

In the current work, a simple, economical, accurate and prices HPLC method with UV detection was developed quantify favipiravir (FVIR) in spiked human plasma using acyclovir (ACVIR) as an international standard in the covid-19 pandemic time both FVIR and ACVIR were well separated resolved on the C18 inertsil column and optimization of variable for FVIR estimation in bulk and pharmaceutical dosage forms. UV visible (200-400nm and400-800nm respectively). UV spectroscopic method was developed for the estimation of FVIR in the bilk and pharmaceutical dosage forms. The solvent selected for the FVIR UV analysis was water, the solution in a range of 2-10µg/ml was scanned in the UV region from 200-400nm and the ƛmax value was determine. The RP-HPLC method was developed on inertsil ODS-3V C18 150mm x 4.6mm x 5micron using buffer pH 3.5; acetonitrile [90; 10] as a mobile phase at flow rate 1.0 ml/min

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