A Study of Process Development of Pharmaceutical Drugs by Liquid Chromatography

Bhaskar Boppa; Dr. Nelu Jain

A Study of Process Development of Pharmaceutical Drugs by Liquid Chromatography

December 2021

Vol-4, Issue-1

Paper ID: 15693

ISSN: 2395-4396

Downloads: 0

Abstract & Details

Research Area

chemistry

Keywords

Process Development Pharmaceutical Drugs Liquid Chromatography Quantifying the Associated Doxazosin Mesylage (DXZN) Liquid Chromatography (LC) DXZN-Related Chemicals.

Abstract

Detectors for separating, identifying, and quantifying the associated doxazosin mesylage (DXZN) substances were developed and validated using a simple and fast reverse phase liquid chromatography (LC) method for monitoring process developments with an electrospray ionisation (ESI)-mass spectrometry system. These DXZN-related chemicals are used as fingerprints to track the HPLC profiles of their manufacturing processes using high-performance liquid chromatography (HPLC). At 265 nm, a photodiode array detector is used with an Inertsil ODS-3 column and an acetonitrile-ammonium acetate solution to carry out the mobile phase separation (10mM, PH 4.0). The LC–ESI-MS–MS may be used to detect additional contaminants generated during synthesis. Data from UV, Fourier transform-IR, 1H NMR, and MS were used to find the pollutants.

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Author Information

#	Name	Institute / Affiliation
1	Bhaskar Boppa	Research Scholar, Department of Chemistry, Sri Satya Sai University of Technology & Medical Sciences, Sehore, M.P., India.
2	Dr. Nelu Jain	Research Guide, Department of Chemistry, Sri Satya Sai University of Technology & Medical Sciences, Sehore, M.P., India.

How to Cite

Use the following formats to cite this article in your research.

APA Style

Boppa, Bhaskar & Jain, Dr. Nelu (2021). A Study of Process Development of Pharmaceutical Drugs by Liquid Chromatography. International Journal of Advance Research and Innovative Ideas In Education, 4(1), 1663-1671.

MLA Style

Boppa, Bhaskar, and Dr. Nelu Jain. "A Study of Process Development of Pharmaceutical Drugs by Liquid Chromatography." International Journal of Advance Research and Innovative Ideas In Education, vol. 4, no. 1, 2021, pp. 1663-1671.

IEEE Style

Bhaskar Boppa and Dr. Nelu Jain, "A Study of Process Development of Pharmaceutical Drugs by Liquid Chromatography," International Journal of Advance Research and Innovative Ideas In Education, vol. 4, no. 1, pp. 1663-1671, 2021.

Vancouver Style

Boppa Bhaskar, Jain Dr. Nelu. A Study of Process Development of Pharmaceutical Drugs by Liquid Chromatography. International Journal of Advance Research and Innovative Ideas In Education. 2021;4(1):1663-1671.

Harvard Style

Boppa, Bhaskar & Jain, Dr. Nelu (2021) 'A Study of Process Development of Pharmaceutical Drugs by Liquid Chromatography', International Journal of Advance Research and Innovative Ideas In Education, 4(1), pp. 1663-1671.

Chicago Style

Boppa, Bhaskar and Dr. Nelu Jain. "A Study of Process Development of Pharmaceutical Drugs by Liquid Chromatography." International Journal of Advance Research and Innovative Ideas In Education 4, no. 1 (2021): 1663-1671.

Turabian Style

Boppa, Bhaskar and Dr. Nelu Jain. "A Study of Process Development of Pharmaceutical Drugs by Liquid Chromatography." International Journal of Advance Research and Innovative Ideas In Education 4, no. 1 (2021): 1663-1671.