"Antimicrobial Activity Withania somnifera (Ashwagandha) By Using Leaf Extract Against Different Bacteria"

Microbiology

The Antimicrobial resistance methodologies and the discovery of novel antimicrobials from plants and other natural sources have been widely used. The genus Withania belong to the soloanaceae family, which comprises 84 genera more than 3,000 species spread around the world.Withania somnifera dunal (WS), commonly known as Ashwagandha in India, belong to the family solanaceae. It is extensively used in most of the Indian herbal pharmaceutical and nutraceuticals. Many plants were used in traditional medicine in many countries. The antimicrobial potential of some solvent extracts of Withania somnifera leaves against different strains of bacteria was investigated. The extensively used of Ashwagandha as a traditional medicine for the treatment of various diseases and observed biological activities were due to secondary metabolites found in the methanolic extract. The present study was aimed to investigate antibacterial activity of methanol extracts of Withania somnifera leaves against parthogenic bacteria. The leaves of Withania somnifera species were collected from town Muradnagar, Ghaziabad, extracted with methanol. Antibacterial activity of crude extracts of Withania somnifera was determined by agar disc diffusion method against gram positive, gram negative bacterial. All tested plant extracts showed varying zones of inhibition against bacteria tested. The highest zone of inhibition of 17mm diameter was noted in Bacillus subtilis with methanol extract while the lowest 7mm zone of inhibition was reported in Escherichia coli. The result obtained exhibit that this plant has good medicinal potential, and it need further phytochemical exploitation to isolate phytochemical constituents having antibacterial activities

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