PHARMACEUTICAL STUDY OF KHAGESHWARA RASA

Medical science

Rasa formulations are very important in Ayurvedic treatment system. Due to its lesser dose, palatability and faster therapeutic effect, Rasaushadhis play a key role in pacifying both local and systemic diseases. Formulations of Rasa Dravyas include Khalwiya Kalpas, Parpati Kalpas, Kupipakwa Kalpas, Pottali Kalpas. Kupipakwa Kalpas are formulations prepared by administering progressive heat is administered for a definite period of time. The final product is a generally a condensed compact formulation which is adhered to the neck (Galastha) or Base (Talastha) of the Kupi or on both (Ubhayastha). Among various integumentary diseases described in Ayurveda, ‘Switra’, where skin becomes hypo pigmented. It may be correlated to ‘Vitiligo’ in modern science .This is one of the most prevalent disease affecting the public domain. ‘Khageshwara Rasa’ is a Kupipakwa Rasayana described in Rasaratnasamuchaya, which is expressed as an effective remedy for managing Switra Roga. The present work is a documentation on the preparation of Khageshwara Rasa conducted in Government Ayurveda College Thiruvananthapuram, India. The work is presumed to be a general guideline for the preparation of this formulation.A mixture of drugs containing 80 gm each of Sudha Parada, Sudha Gandhaka and Sudha Kasisa was done Paaka in Valuka Yantra. The end product obtained was 64.5 gm by weight. Proper assistance, observation and special precautions were required for the successful completion of this product. The chief features in this process was melting of Kajjali, elimination of Sulphur and Water molecules, boiling of Kajjali, liberation of Mercury as vapours, condensation of product and formation of final product which might be predominantly Ferro –Mercuric– Sulphide complex. Modern analytical parameters are required for the structural and compositional identity of the formulation. A hypothetical approach has been carried out, based on the expected action of the drug. Parada with the Yogavahi Karma and Gandhaka with Rasayana Karma may act as a carrier molecule to transport Kasisa. Kasisa is reffered to as ‘Switragna’ in action, which may be due to Ranjana (pigmentation) property and, thereby pigmenting the hypopigmented integumentary zones. Analytical and Clinical studies of the present formulation is yet to be carried out.

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