Antipyretic and Phycopharmacological activity of leaf extract ofGonostegia hirta (Blume ex Hasskarl) Miquel:An important wild food plant of Arunachal Pradesh, India"

Botany

The main objective of this work was to study the antipyretic and analgesic activity of Gonostegia hirta (Blume ex Hasskarl) Miquel of leaf extract in an experimental albino rat model. Antipyretic was evaluated on normal body temperature and Brewer’s yeast-induced pyrexia in albino rat’s model. While phycopharmacological activity of MEGHL was investigate by general behavior and phenobarbitone sodium-induced sleeping time methods.Yeast suspension (10ml/kg b.w) was recorded rectal temperature after 19h of subcutaneous injection. The MEGHL at oral doses of 100, 200 and 300 mg kg-1b.w showed significant reduction in normal body temperature and yeast provoked elevated temperature (37.9±0.2 and 37.6±0.5) in a dose-dependent manner and the anti-pyretic effect was comparable to that of the standard anti-pyretic drug paracetamol(150 mg/kg b.w). MEGHL extract at 100-300 mg kg-1 caused not much reduction in spontaneous activity (general behavior profile) as well as in phenobarbitone sodium-induced sleeping time. This study revealed that the methanol extract of G.hirta possess significant antipyretic activity in the tested models but does not have much activity of phycopharmacological, and may validated its popular use as a antipyretic agents as well as food plant in Adi community of Arunachal Pradesh.

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