Liver Disease in Pregnancy: A Comprehensive Clinical Analysis

Medical (Gynecology)

Introduction: Liver disease in pregnancy represents a spectrum of conditions that pose significant risks to both maternal and fetal health. For the cross-sectional study purpose, major pregnancy-related liver disorders- HELLP syndrome, Pre-eclampsia with hepatic involvement, Intrahepatic Cholestasis of Pregnancy (ICP), Acute Fatty Liver of Pregnancy (AFLP) and Hyperemesis Gravidarum (HG), patients from first affiliated hospital of Xinjiang Medical University, Xinjiang, China was taken. By comparing demographic characteristics, clinical presentation, laboratory parameters, management approaches, and maternal-fetal outcomes across these conditions, we aim to provide clinicians with enhanced understanding of their distinct pathophysiologies and optimal management strategies. Method: A cross-sectional study examined 80 pregnant women with liver disorders treated from November 2023 to November 2024. Demographic data, clinical presentation, laboratory parameters, management approaches, and maternal-fetal outcomes were taken from the day of diagnosis from outpatient and administration department till the delivery of the patient. Statistical analysis was performed. Reference were taken from the PUBMED. Result: HELLP syndrome (n=12) presented with hemolysis, severe thrombocytopenia and hepatic enzyme elevation, resulting in 33.33% perinatal mortality; Pre-eclampsia (n=23) demonstrated significant proteinuria with preserved liver function, showing 8.7% perinatal mortality; ICP (n=45) exhibited pruritus with bile acid elevation, resulting in 13.33% perinatal mortality; AFLP (n=0) and HG (n=0) overall perinatal mortality15% (n=12). Conclusion: Multiparity and elevated BMI were common risk factors across all study. This analysis underscores the necessity for early recognition, multidisciplinary management, and tailored therapeutic approaches to optimize outcomes in these complex obstetric scenarios.

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