Formulation and Development of Nimesulide Micro-Encapsulation by Fluidized Bed Processor

pharamacy,science technology.

A formulation is crucial in ensuring its viability in the current market. Such formulation development is giving rise to new technologies for the creation of products through creative methods; one significant and effective method that is currently being utilized extensively in the pharmaceutical industry is fluid bed technology. This article addresses the many procedures of a fluidized bed processor (FBP) and the underlying idea. FBP has many uses, including drying, pelletizing, granulation powder, or particle coating (micro-encapsulation), and discussing the benefits and drawbacks of the process. Three concepts are involved in the fluid bed process: tangential, bottom, and top sprays. The primary goal is to formulate Nimesulide drug capsules with pre-formulation studies and validation studies included. The polymers used for microencapsulation of Nimesulide are Eudragit RS100 and hydroxypropyl methylcellulose K30 (HPMC K30) followed by 22 factorial designs to get better Quality products. FBP provides pharmaceutical products in low time with excellent therapeutic effects. Another secondary goal is to thoroughly examine and comprehend the mechanism of the micro-encapsulation process by air suspension technique.

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