DIFFERENT APPROACHES FOR SOLUBILITY ENHANCEMENT TECHNIQUES OF TABLET

Pharmaceuticals

Solubility is a property of a material and can be defines as the amount of solute that can dissolve in the specific amount of solvent For achieving therapeutic effect in human , drug should be bioavailable and hence it depends on solubility of drug. Recent studies shows that Most drugs have limited water solubility, making them difficult to dissolve in the GIT area. and causes peptic ulcers , gastric irritation etc, whereas only 8% of drug candidates have high solubility and high permeability . The aim of review is to provide information about the various improvement techniques of solubility and bioavailability of poorly soluble drug and the drugs which causes adverse effects and toxicity due to less absorption and solubility. In BCS classification system class 2 drugs have solubility as rate limiting step hence the enhancement of solubility is an important parameter before formulation of dosage form of that drug.

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