The relationship and risk factors between Ulcerative Colitis and Cholelithiasis

Medical

Abstract Objective: To explore the relationship and risk factors between ulcerative colitis (UC) and cholelithiasis. Methods: A total of 250 UC patients who were admitted to the First Affiliated Hospital of Xinjiang Medical University from September 2019 to October 2023 and had abdominal imaging examinations were selected . According to the inclusion and exclusion criteria, a total of 247 UC patients were included. With the help of imaging examination, the patients were divided into two groups according to the presence or absence of gallstones, including 105 patients with UC with gallstones and 142 patients with UC without gallstones. General data analysis, blood routine and inflammatory factor analysis, biochemical index analysis, clinical symptoms and comorbidity analysis, and disease characteristics analysis were conducted on the two groups of research subjects respectively; single-factor and multi-factor logistic regression analysis were conducted to explore the risk factors of patients with UC combined with cholelithiasis. Results: The majority of patients in the UC with gallstones group were 50-59 years old (39%), and the majority of patients in the UC without gallstones group were <39 years old (55%). Patients in the UC with gallstones group had a drinking history (21.0% vs 9.9%, P<0.05) was higher than that of the group without gallstones; both groups of patients had higher levels of red blood cells, monocytes, aspartate aminotransferase, alanine aminotransferase, creatinine, uric acid, cholesterol, high-density lipoprotein, and low-density lipoprotein. There was a statistically significant difference (P <0.05 ); the difference between the two groups of patients in nausea and vomiting (4.8% vs 54.4%, P <0.05) was statistically significant; the results of multivariate logistic regression analysis showed that monocytes, white blood cells and Protein, C-reactive protein, indirect bilirubin, and uric acid are independent risk factors. Conclusion: In conclusion, our study explored the link between ulcerative colitis (UC) and cholelithiasis, revealing higher prevalence of drinking history in UC patients with gallstones. Elevated blood parameters and biochemical indices suggested potential mechanisms. Multivariate analysis identified monocytes, white blood cells, C-reactive protein, and uric acid as independent risk factors. These findings emphasize the importance of considering demographic and clinical factors in UC management, warranting further research for targeted interventions.

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