THE ETHANOL EXTRACT OF JENGKOL (ARCHIDENDRON PAUCIFLORUM) FRUIT PEEL CAN REPAIR THE HISTOLOGICAL STRUCTURE OF THE TESTES IN MALE WISTAR DIABETIC RAT MODELS

Zoological sciences

Diabetes Mellitus is a major health problem that adversely affects a patient’s life quality worldwide due to its severe complications It has been recognized that chronic hyperglycemia with oxidative stress is a major cause of male infertility. The fruit peel of Jengkol (Archidendron Pauciflorum) is known to contain several antioxidant compounds, such as flavonoids, tannins, saponin, and polyphenols. This study aims to determine the effectiveness of antidiabetic ethanol extract of jengkol fruit peel (EEJFP) in repairing the damage testicular structure in streptozotocin-induced diabetic rats. This research used an experimental method in a laboratory with Completely Random Design (CRD) using 5 treatments and 5 replications. Treatment was administered for 54 consecutive days, comprising a negative control (NC), positive control (PC), comparison (glibenclamide dose 10 mg/kg BW), T1, and T2 (EEJFP dose 385 and 770 mg/kg BW). Diabetic induction was performed with streptozotocin dose of 65 mg/kg BW in male Wistar rats except for the NC group. The parameters observed included morphological aspect of testis (weight, length, width, and volume of testis) and histological structure of testis (seminiferous tubule diameter, lumen diameter, spermatogenic epithelial thickness, and membrane basal thickness). The obtained data were analyzed by ANOVA test and followed by Duncan's test. The results showed that the morphological parameters and histological parameters in the T2 group were not significantly different from the NC group. Based on the study's results, it can be concluded that the EEJFP dose of 770 mg/kg BW is an effective dose in repairing the testicular structure in streptozotocin-induced diabetic male Wistar rats.

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