EFFECTIVENESS OF ETHANOL EXTRACT OF MANGOSTEEN FRUIT PEEL (GARCINIA MANGOSTANA L.) ON ANTI-DYSLIPEDEMIA EFFECTIVENESS IN MALE RATS FED A HIGH-FAT DIET

Clinical Medicine

Dyslipidemia is caused by the disruption of lipid metabolism due to the interaction of genetic and environmental factors. RISKEDAS data also showed that 15.9% of the population aged ≥ 15 years had a very high proportion of LDL (≥ 190 mg/dl), 22.9% had HDL levels less than 40 mg/dl, and 11.9% with very high triglyceride levels (≥ 500 mg/dl). Natural ingredients that have the potential to be an alternative are mangosteen peels. This experimental study uses a Pre-test and Post-test group-only control design approach that uses male Wistar rats as experimental animals, with as many as four male Wistar rats (Rattus norvegicus) in each treatment group—analyzed with One-Way Anova if the data were normally distributed with a follow-up test in the form of a Post Hoc Tukey HSD test to see noticeable differences between treatments. However, if the broadcast data is abnormal, the Kruskal-Wallis test is used as an alternative test. Total cholesterol in all rat treatment groups showed significant differences; this can be seen from the P value <0.05. Triglyceride levels in all treatment groups also showed substantial differences; this can be seen from P < 0.05 (P value = 0.018). The total cholesterol of rats before giving a high-fat diet in all treatment groups did not show significant differences (P value = 0.829). LDL levels also showed significant differences in all treatment groups; this can be seen from the value of P < 0.05. HDL levels also showed significant differences in all treatment groups; this can be seen from P < 0.05 (P value = 0.018). Mangosteen rind ethanol extract can significantly reduce total cholesterol, reduce triglyceride levels, reduce LDL levels, SGOT levels (Value = 0.007), and SGPT (P value < 0.05) compared to the control group. In contrast, mangosteen rind ethanol extract can significantly increase HDL levels compared to the control group (P value = 0.018).

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