Management and prevention strategies for premature birth complications

nursing

Infection is more common at early gestational ages and is associated with major neonatal mortality and morbidity. Abnormal genital tract microflora in early pregnancy predicts late miscarriage and early birth. As a result, many clinicians think that any antibiotic given at any time in pregnancy to any woman at risk of will cause more harm than good. Recent evidence from molecular-based techniques has demonstrated that pre-birth is not a single entity but a syndrome of different sub-types with different etiologies, different microbial communities, and different responses to antibiotics and, in all likelihood, different subsequent phenotypical outcomes from normal term birth to late miscarriage. This manuscript presents those data, the background and attempts to explain the confusion using new information from culture-independent molecular-based techniques. It also gives guidance on the structure of future antibiotic intervention studies.

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