detection of beta lactamase from the clinical isolates of entrococcus species

micro-biology

β-lactamase is an enzyme that deactivates β-lactam antibiotics such as penicillins and cephalosporins. The b-lactam enzyme hydrolyzes (ie, breaks open) the b-lactam ring, destroying the antibacterial properties of the molecule. A sum of 20 clinical isolates of Enterococcus isolates were subjected to antibiotic susceptibility pattern followed by beta lactamase production by tube method. In this method, we have observed 4/20 (20%) of our Enterococcus isolates were found to be β-lactamse positive. As enteroccocus species are frequently isolated from different clinical specimen and the rate of drug sensitivity to different antibiotics have been reduced a lot due to various mechanisms. It is very important role in the selection of drugs and better treatement outcomes.

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