Impact of LEP gene allele's polymorphism on functional traits in Holstein-Friesian cattle.

Veterinary Medicine

The problem of short functional longevity of cattle remains one of the major unsolved problems of agriculture. PCR / RFLP method allows identification of genetic markers that have an advantage in the selection based on functional longevity. Hormone leptin gene is such a marker. Dairy cattle breeding is an important branch of modern world agriculture. In the world there are about 1.5 billion head of cattle (cattle). Therefore, the search for a solution to the problem associated with increasing profitability and production is a priority for workers in agriculture [2]. At the same time, functional longevity is the limiting factor, since it directly affects the lifetime milk yield, the number of offspring and, ultimately, the improvement of breeds and herds [1]. Therefore, in the modern livestock sector, highly productive cows with a long period of use play an extremely important role. To increase the term of functional longevity of cattle by breeding methods will help to search for genetic markers and studies on the evaluation of the connection between SNP markers localized in selected genes and functional longevity of dairy cows. These markers include polymorphisms of the leptin hormone (LEP) gene: R25C, Y7F, A80V [5]. In addition to the influence of the LEP genotype on functional longevity, energy metabolism also depends on food behavior. It may affect the functioning of the immune system and reproductive function, as well as the growth and constitution of animals [4]. It is believed that leptin has a pleiotropic effect on the body.

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