LIPID PROFILE ABNORMALITIES IN NIDDM WOMEN OF NORTH WEST INDIA: A CASE-CONTROL STUDY

South West India

Defect in insulin action or irregularity in insulin secretion or both due to disruption in body’s Lipid metabolism, the major leading cause of NIDDM/T2DM worldwide. The present case control study was conducted on a total of 175 female subjects in which 93 women were NIDDM (cases) and 82 were non- NIDDM (controls), aged from 40-70 years, were present. The patients with any other chronic disease were excluded from the study. Age and biochemical measurements viz., Total serum Cholesterol, Triglycerides, LDL, VLDL and HDL were obtained from their serum. The blood samples from NIDDM patients were obtained in their fasting state. The study disclosed that more abnormalities in all lipid variables i.e. (Triglycerides, Total Cholesterol, HDL, LDL and VLDL) had been seen in NIDDM women’s serum as compared to non- NIDDM women’s serum. The study revealed the pattern of Diabetic Dyslipidemia in NIDDM women which is Low HDL and higher TG- level. The study also concluded that the Triglyceride and Cholesterol were significantly correlated with VLDL and with LDL, respectively and no significant correlation was observed between age and Lipid Variables in the study. Furthermore, as in recent decades, the prevalence of NIDDM has been increased; therefore, nowadays it becomes vital to maintain the lipid metabolism in patients with NIDDM for reducing the prevalence of cardiovascular events as well.

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